- Blue/Green lost to Red in the Indigo League(He may not be a champion yet, but still).
- Lance was ambushed and defeated by Team Rocket, presumably Petrel. (HGSS) Also, he got beaten up
- Steven died trying to control Regirock, Registeel, and Regice.
- Wallace got beaten to a pulp trying to save his girlfriend from being choked to death.
- Cynthia challenged Cyrus to a battle in the Veilstone Galactic building and lost.
- Alder got defeated 4-on-4 by N.
Pokemon Special really hates their Regional Champions, don't they?
At least they make the champions look good. Very good. We love you, Pokemon Special.